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Endometrial cancer is the most commonly diagnosed gynaecological cancer. Based on differences in clinic pathologic characteristics, there are two subtypes of endometrial carcinoma Type 1 and Type 2. Multiple risk factors (Obesity, use of an intrauterine device, Age, Diet and Exercise, Type 2 Diabetes) are developing endometrial cancer. Likewise, epigenetics is the study of alteration gene and modulated gene expression with alteration in DNA sequences. In mammals, epigenetic modifications include DNA methylation, histone modifications, and miRNA.